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Anastrozole is removed slowly in the plasma, having a half-life of 40 to 50 hours. Anastrozole is extensively metabolized by postmenopausal women, with less than 10% of the dosage eliminated unchanged in urine within 72 hours of dosing. The half-life of a medication is the time it takes for half of the substance to be processed and removed by the body. Anastrozole's half-life is approximately 46.8 hours. This means it takes around 46.8 hours for the anastrozole concentration in the bloodstream to drop by 50% following injection. Individual characteristics, such as metabolism, liver function, and concurrent use of drugs, can all have an impact on a person's half-life. As a result, while the average half-life of anastrozole is around 46.8 hours, the actual duration may differ from person to person.
